2,6-Dibromophenol → HCID 59382965, compound

Participants

Reaction Steps

A stirred mixture of 2,6-dibromophenol (946 mg, 3.76 mmol), Cu2O (322 mg, 2.25 mmol), 4-methylpentyne (0.5 mL, 3.9 mmol) and pyridine (5 mL) was heated at vigorous reflux for 0.5 h. The mixture was concentrated under reduced pressure to remove pyridine, diluted with ether (100 mL), washed with water (50 mL), 5% aq HCl (2×50 mL) and 1M aq NaOH (50 mL) and dried over MgSO4. Removal of the solvent left an oil (650 mg) containing 7-bromo-2-isobutylbenzofuran (˜70% pure).

Provenance & Evidence