Lithium hydroxide, monohydrate → (R)-2-(1-allyl-2-(1-phenylethylcarbamoyl)hydrazinyl)acetic acid

Participants

Reaction Steps

According to the procedure described in the synthesis method of Compound VI-2 with the modification that the reaction was carried out for 2 hours, (R)-ethyl 2-(1-allyl-2-(1-phenylethylcarbamoyl)hydrazinyl)acetate (Compound V-3) 229 mg (0.75 mmol) was reacted with lithium hydroxide monohydrate 38 mg (0.9 mmol) to obtain the title compound 202 mg (97%).

Provenance & Evidence