HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Chlorothieno[3,2-b]pyridine-3-carbaldehyde → (S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Chlorothieno[3,2-b]pyridine-3-carbaldehyde | HCID 1476264 | — |
| Edukt | (2S)-1,1-Diethoxy-2-propanamine | HCID 12398111 | — |
| Produkt | (S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine | HCID 86652569 | 30,3% |
Reaktionsschritte
According to the procedure described in the synthesis method of Compound IX-2, (S)-1,1-diethoxypropan-2-amine (Compound XIX-1) 1.98 g (13.4 mmol) was reacted with 5-chlorothieno[3,2-b]pyridine-3-carbaldehyde (Compound XX-1) 1.98 g (10 mmol) and purified on Buch silica gel column chromatography (chloroform:methanol=98:2 to 95:5) to obtain the title compound 996 mg (30%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08455488B2 |
| Quelldatensatz | uspto-grants-2013_06 |
| ORD ID | ord-59d8fbcde2224c5c80818efb296542a3 |
| Quellennotiz | uspto-grants-2013_06 |