Fmoc-L-Tyr(tBu)-OH → (9H-fluoren-9-yl)methyl (S)-3-(4-tert-butoxyphenyl)-1-(((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)((S)-1,1-diethoxypropan-2-yl)amino)-1-oxopropan-2-ylcarbamate

Participants

Role	Name	HCID	Charge
Reactant	Fmoc-L-Tyr(tBu)-OH	HCID 10895791	—
Reactant	(S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine	HCID 86652569	—
Product	(9H-fluoren-9-yl)methyl (S)-3-(4-tert-butoxyphenyl)-1-(((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)((S)-1,1-diethoxypropan-2-yl)amino)-1-oxopropan-2-ylcarbamate	HCID 86698529	—

Reaction Steps

According to the procedure described in the synthesis method of Compound III-1, (S)—N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine (Compound IX-7) 996 mg (3.03 mmol) was coupled with (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoic acid

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08455488B2
Source dataset	uspto-grants-2013_06
ORD ID	ord-4d0a06a283ea45e9b4b8c5dc50175a60
Source note	uspto-grants-2013_06