HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminum hydride → 5-(4-Trifluoromethylphenyl)-6-phenylpyridine-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | Ethyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate | HCID 68408073 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(4-Trifluoromethylphenyl)-6-phenylpyridine-2-carbaldehyde | HCID 86619071 | — |
Reaction Steps
Following General Procedure L, ethyl 5-(4-trifluoromethylphenyl)-6-phenylpyridine-2-carboxylate (Compound 25, 74 mg, 0.20 mmol) and DIBAL-H (0.3 ml, 0.30 mmol, 1.0 M in hexane) in CH2Cl2 (3 ml) were reacted to produce the title compound after purification by column chromatography (silica gel, 15% ethyl acetate in hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728014B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-25cfcf96b25d4fc6b54c9b584a00826c |
| Source note | uspto-grants-2010_06 |