HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-((4-Chlorobenzyl)carbamoyl)-1-methylhydrazinyl)acetic acid → tert-butyl (S)-5-(2-(2-(4-chlorobenzylcarbamoyl)-1-methylhydrazinyl)acetamido)-6-(((S)-1,1-diethoxypropan-2-yl)(naphthalen-1-ylmethyl)amino)-6-oxohexylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-((4-Chlorobenzyl)carbamoyl)-1-methylhydrazinyl)acetic acid | HCID 53397501 | — |
| Reactant | tert-butyl (S)-5-amino-6-(((S)-1,1-diethoxypropan-2-yl)(naphthalen-1-ylmethyl)amino)-6-oxohexylcarbamate | HCID 86698537 | — |
| Product | tert-butyl (S)-5-(2-(2-(4-chlorobenzylcarbamoyl)-1-methylhydrazinyl)acetamido)-6-(((S)-1,1-diethoxypropan-2-yl)(naphthalen-1-ylmethyl)amino)-6-oxohexylcarbamate | HCID 86761871 | — |
Reaction Steps
According to the procedure described in the synthesis method of Compound II-15, 2-(2-(4-chlorobenzylcarbamoyl)-1-methylhydrazinyl)acetic acid (Compound VI-7) 79 mg (0.29 mmol) was coupled with tert-butyl (S)-5-amino-6-(((S)-1,1-diethoxypropan-2-yl)-(naphthalen-1-ylmethyl)amino)-6-oxohexylcarbamate (Compound IV-13) 100 mg (0.19 mmol) to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455488B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-8fb68ab2468d4d63b89f0db4584702c8 |
| Source note | uspto-grants-2013_06 |