2-(2-(Benzylcarbamoyl)-1-methylhydrazinyl)acetic acid → HCID 86698543, compound

HRID 1254573Notes

Reaction equation

HRID 1254573 reaction equation
[CH2:1]([NH:8][C:9]([NH:11][N:12]([CH2:14][C:15]([OH:17])=O)[CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:18][C@H:19]([C:32]([N:34]([CH2:44][C:45]1[C:46]2[CH:53]=[CH:52][CH:51]=[CH:50][C:47]=2[S:48][CH:49]=1)[C@@H:35]([CH3:43])[CH:36]([O:40][CH2:41][CH3:42])[O:37][CH2:38][CH3:39])=[O:33])[CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28]>>[S:48]1[CH:49]=[C:45]([CH2:44][N:34]([C@@H:35]([CH3:43])[CH:36]([O:37][CH2:38][CH3:39])[O:40][CH2:41][CH3:42])[C:32](=[O:33])[C@@H:19]([NH:18][C:15](=[O:17])[CH2:14][N:12]([CH3:13])[NH:11][C:9](=[O:10])[NH:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:20][CH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:31])[O:26][C:27]([CH3:29])([CH3:28])[CH3:30])[C:46]2[CH:53]=[CH:52][CH:51]=[CH:50][C:47]1=2

Participants

3

Reactant 2

HCID 533974892-(2-(Benzylcarbamoyl)-1-methylhydrazinyl)acetic acidHCID 86698544HCID 86698544, compound2×

Product 1

HCID 86698543HCID 86698543, compound

Procedure

According to the procedure described in the synthesis method of Compound II-15, 2-(2-(benzylcarbamoyl)-1-methylhydrazinyl)acetic acid (Compound VI-3) 68 mg (0.29 mmol) was coupled with tert-butyl (S)-5-amino-6-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-6-oxohexylcarbamate (Compound IV-15) 100 mg (0.19 mmol) to obtain the title compound.

Sources & evidence

ORD record
ord-f8b6a2a1d4364b87a76aa38c5703f3b7
Source dataset
uspto-grants-2013_06
Patent number
US08455488B2

Reaction notes

Loading…