2-(2-((4-Chlorobenzyl)carbamoyl)-1-methylhydrazinyl)acetic acid → HCID 86698545, compound

HRID 1254574Notes

Reaction equation

HRID 1254574 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][C:8]([NH:10][N:11]([CH2:13][C:14]([OH:16])=O)[CH3:12])=[O:9])=[CH:4][CH:3]=1.[NH2:19][C@H:20]([C:33]([N:35]([CH2:45][C:46]1[C:47]2[CH:54]=[CH:53][CH:52]=[CH:51][C:48]=2[S:49][CH:50]=1)[C@@H:36]([CH3:44])[CH:37]([O:41][CH2:42][CH3:43])[O:38][CH2:39][CH3:40])=[O:34])[CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29]>>[S:49]1[CH:50]=[C:46]([CH2:45][N:35]([C@@H:36]([CH3:44])[CH:37]([O:38][CH2:39][CH3:40])[O:41][CH2:42][CH3:43])[C:33](=[O:34])[C@@H:20]([NH:19][C:14](=[O:16])[CH2:13][N:11]([CH3:12])[NH:10][C:8](=[O:9])[NH:7][CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:18][CH:17]=2)[CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:26](=[O:32])[O:27][C:28]([CH3:30])([CH3:29])[CH3:31])[C:47]2[CH:54]=[CH:53][CH:52]=[CH:51][C:48]1=2

Participants

3

Reactant 2

HCID 533975012-(2-((4-Chlorobenzyl)carbamoyl)-1-methylhydrazinyl)acetic acidHCID 86698544HCID 86698544, compound

Product 1

HCID 86698545HCID 86698545, compound

Procedure

According to the procedure described in the synthesis method of Compound II-15, 2-(2-(4-chlorobenzylcarbamoyl)-1-methylhydrazinyl)acetic acid (Compound VI-7) 78 mg (0.29 mmol) was coupled with tert-butyl (S)-5-amino-6-((benzo[b]thiophen-3-ylmethyl)-((S)-1,1-diethoxypropan-2-yl)amino)-6-oxohexylcarbamate IV-15) 100 mg (0.19 mmol) to obtain the title compound.

Sources & evidence

ORD record
ord-4514739fb9b54f68be7da7b4226ae384
Source dataset
uspto-grants-2013_06
Patent number
US08455488B2

Reaction notes

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