2-(2-(Ethylcarbamoyl)-1-methylhydrazinyl)acetic acid → HCID 86698546, compound

HRID 1254575Notes

Reaction equation

HRID 1254575 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][N:7]([CH2:9][C:10]([OH:12])=O)[CH3:8])=[O:5])[CH3:2].[NH2:13][C@H:14]([C:27]([N:29]([CH2:39][C:40]1[C:41]2[CH:48]=[CH:47][CH:46]=[CH:45][C:42]=2[S:43][CH:44]=1)[C@@H:30]([CH3:38])[CH:31]([O:35][CH2:36][CH3:37])[O:32][CH2:33][CH3:34])=[O:28])[CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23]>>[S:43]1[CH:44]=[C:40]([CH2:39][N:29]([C@@H:30]([CH3:38])[CH:31]([O:32][CH2:33][CH3:34])[O:35][CH2:36][CH3:37])[C:27](=[O:28])[C@@H:14]([NH:13][C:10](=[O:12])[CH2:9][N:7]([CH3:8])[NH:6][C:4](=[O:5])[NH:3][CH2:1][CH3:2])[CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:24])([CH3:23])[CH3:25])[C:41]2[CH:48]=[CH:47][CH:46]=[CH:45][C:42]1=2

Participants

3

Reactant 2

HCID 533974172-(2-(Ethylcarbamoyl)-1-methylhydrazinyl)acetic acidHCID 86698544HCID 86698544, compound2×

Product 1

HCID 86698546HCID 86698546, compound

Procedure

According to the procedure described in the synthesis method of Compound II-15, 2-(2-(ethylcarbamoyl)-1-methylhydrazinyl)acetic acid (Compound VI-9) 50 mg (0.29 mmol) was coupled with tert-butyl (S)-5-amino-6-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxy-propan-2-yl)amino)-6-oxohexylcarbamate (Compound IV-15) 100 mg (0.19 mmol) to obtain the title compound.

Sources & evidence

ORD record
ord-ffd1da0c97474f47a743e8f7f06b39f4
Source dataset
uspto-grants-2013_06
Patent number
US08455488B2

Reaction notes

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