HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-(Naphthalen-1-ylmethyl)ureidooxy)acetic acid → 1-(2-((S)-1-(((S)-1,1-diethoxypropan-2-yl)(naphthalen-1-ylmethyl)amino)-1-oxopropan-2-ylamino)-2-oxoethoxy)-3-(naphthalen-1-ylmethyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-(Naphthalen-1-ylmethyl)ureidooxy)acetic acid | HCID 53397538 | — |
| Reactant | (S)-2-amino-N-((S)-1,1-diethoxypropan-2-yl)-N-(naphthalen-1-ylmethyl)-propanamide | HCID 67075246 | — |
| Product | 1-(2-((S)-1-(((S)-1,1-diethoxypropan-2-yl)(naphthalen-1-ylmethyl)amino)-1-oxopropan-2-ylamino)-2-oxoethoxy)-3-(naphthalen-1-ylmethyl)urea | HCID 86652592 | — |
Reaction Steps
According to the procedure described in the synthesis method of Compound II-15, 2-(3-(naphthalen-1-ylmethyl)ureidooxy)acetic acid (Compound VI-12) 115 mg (0.42 mmol) was coupled with (S)-2-amino-N—((S)-1,1-diethoxypropan-2-yl)-N-(naphthalen-1-ylmethyl)-propanamide (Compound IV-10) 100 mg (0.28 mmol) to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455488B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-154f6359d4bd4e9aa46c16dd3416110a |
| Source note | uspto-grants-2013_06 |