HRID1254613

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53397416

未命名化合物

结构：CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1

HCID67075252

未命名化合物

PRODUCTS

生成物

结构：CCNC(=O)NOCC(=O)N[C@@H](Cc1ccc(OC(C)(C)C)cc1)C(=O)N(Cc1csc2ccccc12)[C@@H](C)C(OCC)OCC

HCID86652618

未命名化合物

PROCEDURE

实验过程

According to the procedure described in the synthesis method of Compound II-15, 2-(3-ethylureidooxy)acetic acid (Compound VI-13) 47 mg (0.29 mmol) was coupled with (S)-2-amino-N-(benzo[b]thiophen-3-ylmethyl)-3-(4-tert-butoxyphenyl)-N—((S)-1,1-diethoxypropan-2-yl)propanamide (Compound IV-6) 100 mg (0.20 mmol) to obtain the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5ea7fa0b8fba4b8c865ba2bb2d604838
来源数据集: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08455488B2
来源说明: uspto-grants-2013_06

反应 SMILES

[CH2:1]([NH:3][C:4](=[O:11])[NH:5][O:6][CH2:7][C:8]([OH:10])=O)[CH3:2].[NH2:12][C@@H:13]([CH2:36][C:37]1[CH:42]=[CH:41][C:40]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[CH:39][CH:38]=1)[C:14]([N:16]([CH2:26][C:27]1[C:28]2[CH:35]=[CH:34][CH:33]=[CH:32][C:29]=2[S:30][CH:31]=1)[C@@H:17]([CH3:25])[CH:18]([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])=[O:15]>>[S:30]1[CH:31]=[C:27]([CH2:26][N:16]([C@@H:17]([CH3:25])[CH:18]([O:19][CH2:20][CH3:21])[O:22][CH2:23][CH3:24])[C:14](=[O:15])[C@@H:13]([NH:12][C:8](=[O:10])[CH2:7][O:6][NH:5][C:4]([NH:3][CH2:1][CH3:2])=[O:11])[CH2:36][C:37]2[CH:38]=[CH:39][C:40]([O:43][C:44]([CH3:45])([CH3:47])[CH3:46])=[CH:41][CH:42]=2)[C:28]2[CH:35]=[CH:34][CH:33]=[CH:32][C:29]1=2