HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopropylphosphonic acid → (3-(((6-Phenyl-5-(p-tolyl)pyridin-2-yl)methyl)amino)propyl)phosphonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopropylphosphonic acid | HCID 97587 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 6-Phenyl-5-p-tolylpyridine-2-carbaldehyde | HCID 86619072 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (3-(((6-Phenyl-5-(p-tolyl)pyridin-2-yl)methyl)amino)propyl)phosphonic acid | HCID 44234515 | — |
Reaction Steps
Following General Procedure M, 6-phenyl-5-p-tolylpyridine-2-carbaldehyde (Compound 55, 67 mg, 0.25 mmol), (3-aminopropyl)-phosphonic acid (34 mg, 0.25 mmol), Bu4NOH (0.2 ml, 0.25 mmol, 1 M in MeOH) and NaCNBH3 (15 mg, 0.25 mmol) in MeOH (3 ml) were reacted to produce the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728014B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-022616730b0b4007b11ba681d49f496b |
| Source note | uspto-grants-2010_06 |