Cis-2-boc-hexahydropyrrolo[3,4-C]pyrrole → HCID 44469409, compound

HRID 1254815Notes

Reaction equation

HRID 1254815 reaction equation
Br[C:2]1[N:7]=[C:6]([NH:8][C:9]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:22][CH3:23])=[CH:19][CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[O:10])[CH:5]=[N:4][CH:3]=1.[CH2:24]1[C@@H:28]2[CH2:29][NH:30][CH2:31][C@@H:27]2[CH2:26][N:25]1[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33]>>[CH3:23][O:22][C:18]1[CH:17]=[C:16]2[C:21]([C:12]([NH:11][C:9](=[O:10])[NH:8][C:6]3[N:7]=[C:2]([N:30]4[CH2:29][C@@H:28]5[CH2:24][N:25]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:26][C@@H:27]5[CH2:31]4)[CH:3]=[N:4][CH:5]=3)=[CH:13][CH:14]=[N:15]2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 1514452Cis-2-boc-hexahydropyrrolo[3,4-C]pyrroleHCID 86653030HCID 86653030, compound

Product 1

HCID 44469409HCID 44469409, compoundYield 65%

Procedure

The compound was prepared by the method described for Example 1 using 1-(6-bromopyrazin-2-yl)-3-(7-methoxyquinolin-4-yl)urea and (3aR,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate as starting compounds and was obtained as a white solid (96 mg, 65%).

Workup

  1. customThe compound was prepared by the method

Sources & evidence

ORD record
ord-e006d5e25140446cbb6e6a267f61ece8
Source dataset
uspto-grants-2013_06
Patent number
US08455648B2

Reaction notes

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