(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane → HCID 67187836, compound

HRID 1254816Notes

Reaction equation

HRID 1254816 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]([NH:15][C:16]3[CH:21]=[N:20][CH:19]=[CH:18][N:17]=3)=[O:14])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C@H:22]12[CH2:28][C@H:25]([NH:26][CH2:27]1)[CH2:24][N:23]2[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>>[N:17]1[CH:18]=[CH:19][N:20]=[CH:21][C:16]=1[NH:15][C:13](=[O:14])[NH:12][C:6]1[C:5]2[C:10](=[CH:11][C:2]([N:26]3[CH2:27][C@@H:22]4[CH2:28][C@H:25]3[CH2:24][N:23]4[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[CH:3][CH:4]=2)[N:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptaneHCID 24859298HCID 24859298, compound

Product 1

HCID 67187836HCID 67187836, compound

Procedure

The compound was prepared by the method described for Example 1 using 1-(7-bromoquinolin-4-yl)-3-(pyrazin-2-yl)urea and (1S,4S)-tert-butyl 2,5-diazabicyclo[2.2.1]-heptane-2-carboxylate as starting compounds.

Workup

  1. customThe compound was prepared by the method

Sources & evidence

ORD record
ord-85ab6c84e950419497b7b387da9375be
Source dataset
uspto-grants-2013_06
Patent number
US08455648B2

Reaction notes

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