HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 2-chloro-N-(isoquinolin-6-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Chloroacetic Acid | HCID 300 | — |
| Reactant | 6-Aminoisoquinoline | HCID 588991 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-chloro-N-(isoquinolin-6-yl)acetamide | HCID 24999501 | — |
Reaction Steps
To chloroacetic acid in DMF was added EDC, DMAP and 6-aminoisoquinoline. This mixture was stirred for 4 hours. The reaction was washed with NaHCO3(sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, 5% MeOH/CH2Cl2) gave 2-chloro-N-(isoquinolin-6-yl)acetamide (E1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455647B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-52c587bdd6a840ed90e7270b93d24eb8 |
| Source note | uspto-grants-2013_06 |