3-Chloro-4-fluorobenzaldehyde → 4-(Bromomethyl)-2-chloro-1-(methylsulfonyl)benzene

HRID 1254903Notes

Reaction equation

HRID 1254903 reaction equation
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[C:5](F)[CH:4]=1.[Cl:14]C1C=C(C=CC=1F)C=O>>[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[C:5]([Cl:14])[CH:4]=1

Participants

3

Reactant 2

HCID 5938663-Chloro-4-fluorobenzaldehydeHCID 672190653-Fluoro-4-(methylsulphonyl)benzyl bromide

Product 1

HCID 179665394-(Bromomethyl)-2-chloro-1-(methylsulfonyl)benzene

Procedure

The titled compound is prepared analogously to 4-bromomethyl-2-fluoro-1-methanesulfonyl-benzene by replacing 3,4-difluorobenzaldehyde with 3-chloro-4-fluoro-benzaldehyde.

Sources & evidence

ORD record
ord-639c5e5879a3458b91b3c6121c84e1a5
Source dataset
uspto-grants-2013_06
Patent number
US08455645B2

Reaction notes

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