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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1254919Generated: November 3, 2026

4-Amino-2-chlorobenzonitrile → 3-Chloro-4-cyanobenzene-1-sulfonyl chloride

https://huagongshe.com/reaction/1254919

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Amino-2-chlorobenzonitrileHCID 88728—
Reactant4-Fluoro-3-methoxybenzenesulfonyl chlorideHCID 2783408—
Product3-Chloro-4-cyanobenzene-1-sulfonyl chlorideHCID 18071892—

Reaction Steps

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 4-amino-2-chloro-benzonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08455645B2
Source datasetuspto-grants-2013_06
ORD IDord-7be7c9d6208841f8ab74bda7d3ff1e97
Source noteuspto-grants-2013_06