[1-(4-Fluoro-3-methoxy-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid → [1-(3-Cyano-4-morpholin-4-yl-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid

HRID 1254927Notes

Reaction equation

HRID 1254927 reaction equation
FC1C=CC(S(N2C3=NC=CC=C3C(CC(O)=O)=C2C)(=O)=O)=CC=1OC.C[O:28][C:29](=[O:58])[CH2:30][C:31]1[C:39]2[C:34](=[N:35][CH:36]=[CH:37][CH:38]=2)[N:33]([S:40]([C:43]2[CH:48]=[CH:47][C:46]([N:49]3[CH2:54][CH2:53][O:52][CH2:51][CH2:50]3)=[C:45]([C:55]#[N:56])[CH:44]=2)(=[O:42])=[O:41])[C:32]=1[CH3:57]>>[C:55]([C:45]1[CH:44]=[C:43]([S:40]([N:33]2[C:34]3=[N:35][CH:36]=[CH:37][CH:38]=[C:39]3[C:31]([CH2:30][C:29]([OH:58])=[O:28])=[C:32]2[CH3:57])(=[O:42])=[O:41])[CH:48]=[CH:47][C:46]=1[N:49]1[CH2:54][CH2:53][O:52][CH2:51][CH2:50]1)#[N:56]

Participants

3

Reactant 2

HCID 45268524[1-(4-Fluoro-3-methoxy-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acidHCID 67219557[1-(3-Cyano-4-morpholin-4-yl-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid methyl ester

Product 1

HCID 23582407[1-(3-Cyano-4-morpholin-4-yl-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid

Procedure

The titled compound is prepared analogously to [1-(4-fluoro-3-methoxy-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid (Example 102) by replacing [1-(4-fluoro-3-methoxy-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid methyl ester with [1-(3-cyano-4-morpholin-4-yl-benzenesulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]acetic acid methyl ester. (MH+ 441)

Sources & evidence

ORD record
ord-937d3d9df15447118773631266a18142
Source dataset
uspto-grants-2013_06
Patent number
US08455645B2

Reaction notes

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