HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobutylphosphonic acid → 4-((5-(4-Ethylphenyl)-6-phenylpyridin-2-yl)methylamino)butylphosphonic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobutylphosphonic acid | HCID 1726 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 5-(4-Ethylphenyl)-6-phenylpyridine-2-carbaldehyde | HCID 86619074 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-((5-(4-Ethylphenyl)-6-phenylpyridin-2-yl)methylamino)butylphosphonic Acid | HCID 59504165 | — |
Reaction Steps
Following General Procedure M, 5-(4-ethyl-phenyl)-6-phenyl-pyridine-2-carbaldehyde (Compound 56, 58 mg, 0.18 mmol), 4-aminobutylphosphonic acid (21 mg, 0.18 mmol), Bu4NOH (0.18 ml, 0.18 mmol, 1 M in MeOH) and NaCNBH3 (9 mg, 0.18 mmol) in MeOH (2 ml) were reacted to produce the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728014B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-fb5a8aadbc52484ba89b37b93942889d |
| Source note | uspto-grants-2010_06 |