Dimethylformamide → N-(5-(7-Cyanobenzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	N-(5-(7-Bromobenzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide	HCID 24765405	—
촉매	Zinc cyanide (Zn(CN)2)	HCID 11186	—
촉매	HCID 178418397	HCID 178418397	—
용매	Ethyl Acetate	HCID 8857	—
생성물	N-(5-(7-Cyanobenzo[d][1,3]dioxol-5-yl)-4-methylthiazol-2-yl)-2,6-difluorobenzamide	HCID 24765407	—

반응 조건

온도	100 °C

반응 단계

A degassed mixture of Compound 56 (80 mg, 0.18 mmol), zinc cyanide (26 mg, 0.22 mmol) and tetrakis(triphenylphosphine)palladium (20.0 mg, 0.017 mmol) in DMF (2.0 mL) was heated to 100° C. overnight. The mixture was cooled to room temperature, diluted with ethyl acetate. The mixture was washed with a solution of saturated NaHCO3 then with brine, dried (Na2SO4), filtered and concentrated. The residue was purified on silica to provide Compound 58 (55 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08455658B2
출처 데이터셋	uspto-grants-2013_06
ORD ID	ord-ba6a557094f04c3688ab46c12cb7dc7f
출처 메모	uspto-grants-2013_06