HCID 24765490, compound → 2,6-Difluoro-N-(4-(1-hydroxyethyl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide
Reaction equation
FC1C=CC=C(F)C=1C(NC1SC(C2C=CC=C(C(F)(F)F)C=2)=C(C=O)N=1)=O.C[Mg+].[Br-].[F:32][C:33]1[CH:60]=[CH:59][CH:58]=[C:57]([F:61])[C:34]=1[C:35]([NH:37][C:38]1[S:39][C:40]([C:47]2[CH:52]=[CH:51][CH:50]=[C:49]([C:53]([F:56])([F:55])[F:54])[CH:48]=2)=[C:41]([C:43]([OH:46])(C)[CH3:44])[N:42]=1)=[O:36]>>[F:32][C:33]1[CH:60]=[CH:59][CH:58]=[C:57]([F:61])[C:34]=1[C:35]([NH:37][C:38]1[S:39][C:40]([C:47]2[CH:52]=[CH:51][CH:50]=[C:49]([C:53]([F:56])([F:54])[F:55])[CH:48]=2)=[C:41]([CH:43]([OH:46])[CH3:44])[N:42]=1)=[O:36]Participants
4
Procedure
Compound 74 was prepared from Compound 67 and MeMgBr similarly as described for the preparation of Compound 68.
Sources & evidence
- ORD record
- ord-a1a14f2d6eca426aa95ebf1f4a71cebc
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08455658B2
Reaction notes
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