Water → HCID 24765776, compound

Participants

Reaction Steps

To the solution of Compound 93 (220 mg, 0.47 mmol) in 10 mL of anhydrous THF was added MeMgBr (3.0 M in Et2O, 0.5 mL) at −78° C. The solution was slowly warmed to room temperature over 2 hours. The reaction mixture was treated with 10 mL of water. The mixture was extracted with Et2O, the combined organic phases were dried (Na2SO4) and concentrated. The residue was purified by column chromatography on silica gel (eluted with 10-100% ethyl acetate in hexanes) to give Compound 94 (184 mg, 83%) as a white solid.

Provenance & Evidence