2-Bromo-6-methylpyridine → HCID 24765974, compound

HRID 1255150Notes

Reaction equation

HRID 1255150 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N:3]=1.[F:9][C:10]1[CH:39]=[CH:38][CH:37]=[C:36]([F:40])[C:11]=1[C:12]([NH:14][C:15]1[S:16][C:17]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)=[C:18](C2C=CC=CN=2)[N:19]=1)=[O:13]>>[F:40][C:36]1[CH:37]=[CH:38][CH:39]=[C:10]([F:9])[C:11]=1[C:12]([NH:14][C:15]1[S:16][C:17]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)=[C:18]([C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N:3]=2)[N:19]=1)=[O:13]

Participants

3

Reactant 2

HCID 792052-Bromo-6-methylpyridineHCID 247659732,6-Difluoro-N-(4-(pyridin-2-yl)-5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)benzamide

Product 1

HCID 24765974HCID 24765974, compound

Procedure

Compound 108 was prepared from 22a and 2-bromo-6-methylpyridine as described for the preparation of Compound 107.

Sources & evidence

ORD record
ord-65952a6229b14ea0962b378893429337
Source dataset
uspto-grants-2013_06
Patent number
US08455658B2

Reaction notes

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