HRID1255163
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 70 °C
PROCEDURE
实验过程
To a flask containing the title compound from Example 2 Step A (40.0 mg, 0.073 mmol) were added 4-trifluoromethylphenyl boronic acid (21.0 mg, 0.110 mmol) and dichlorobis(triphenylphosphine)palladium(II) (2.6 mg, 0.004 mmol). Degassed acetonitrile (0.5 mL) and sodium carbonate (0.183 mL, 1.0 M aqueous, 0.183 mmol) were added, and the reaction mixture was stirred at 70° C. After 1.5 h, the reaction mixture was allowed to cool to ambient temperature, then was filtered through a short plug of silica gel, eluting with DCM. The Suzuki product was used in the subsequent step without further purification: LCMS m/z 612.2 [M+H]+.
WORKUP
后处理
- temperatureto cool to ambient temperature
- filtrationwas filtered through a short plug of silica gel
- washeluting with DCM
- customThe Suzuki product was used in the subsequent step without further purification