Triphenylphosphine → HCID 86633491, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the title compound from Example 7 Step A (30.0 mg, 0.060 mmol) and 4-hydroxybenzotrifluoride (29.3 mg, 0.181 mmol) in THF (0.400 mL) were added triphenylphosphine (47.5 mg, 0.181 mmol) and diisopropyl azodicarboxylate (0.035 mL, 0.181 mmol). The resulting mixture was stirred at 60° C. After 3.5 h, the mixture was allowed to cool to ambient temperature, then was concentrated in vacuo. Purification by flash chromatography on silica gel (0 to 50% EtOAc in hexanes, then 50 to 100% EtOAc in hexanes) provided the title compound: LCMS m/z 642.3 [M+H]+.

Provenance & Evidence