HCID 67159582, compound → HCID 67159662, compound

Participants

Reaction Steps

To a degassed solution of the title compound from Example 13 Step B (606 mg, 2.10 mmol) in EtOAc (15 mL) was added platinum(IV) oxide (150 mg). The reaction mixture was fitted with a 3-way adapter with a hydrogen balloon attached. The reaction flask was then evacuated and back-filled with hydrogen. After this process was repeated three times, the reaction mixture was placed under a hydrogen atmosphere, then was stirred vigorously. After 45 min, the reaction mixture was filtered through Celite, rinsing with EtOAc. The mixture was then concentrated in vacuo to provide the title compound, which was used without further purification: LCMS m/z 259.4 [M−CH3O]+.

Provenance & Evidence