Sodium Carbonate → HCID 86633492, compound

Participants

Reaction Steps

To a vial containing the title compound from Example 14 Step A (14.0 mg, 0.024 mmol) were added 3-bromo-6-trifluoromethylpyridine (6.4 mg, 0.028 mmol) and trans-dichlorobis(triphenylphosphine) palladium (II) (1.7 mg, 0.0024 mmol). Acetonitrile (0.500 mL) and sodium carbonate (0.059 mL, 1.0 M in water, 0.059 mmol) were added, and the resulting mixture was degassed by a nitrogen sparge. The reaction vial was capped and placed in a pre-heated oil bath (70° C.). After 6 h, the reaction mixture was allowed to cool to room temperature, then was purified by flash chromatography on silica gel: LCMS m/z 613.2 [M+H]+.

Provenance & Evidence