[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanol → 1-[2'-{[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-5'-(trifluoromethyl)-2,3'-bipyridin-6-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Reaction equation
F[C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N:14]3[C:18]([C:19]([F:22])([F:21])[F:20])=[C:17]([C:23]([O:25]CC)=[O:24])[CH:16]=[N:15]3)[N:9]=2)=[CH:6][C:5]([C:28]([F:31])([F:30])[F:29])=[CH:4][N:3]=1.[CH3:32][C:33]1[CH:34]=[C:35]([C:41]2[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][CH:42]=2)[CH:36]=[CH:37][C:38]=1[CH2:39][OH:40]>>[CH3:32][C:33]1[CH:34]=[C:35]([C:41]2[CH:46]=[CH:45][C:44]([C:47]([F:48])([F:49])[F:50])=[CH:43][CH:42]=2)[CH:36]=[CH:37][C:38]=1[CH2:39][O:40][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N:14]3[C:18]([C:19]([F:22])([F:20])[F:21])=[C:17]([C:23]([OH:25])=[O:24])[CH:16]=[N:15]3)[N:9]=2)=[CH:6][C:5]([C:28]([F:30])([F:31])[F:29])=[CH:4][N:3]=1Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared according to the procedure described in Example 237 Step B, by reaction of the title compound from Example 240 Step A with [3-methyl-4′-(trifluoromethyl)biphenyl-4-yl]methanol (PCT Publication WO2005118542): LCMS m/z 666.8 [M+H]+; 1H NMR (500 MHz, acetone-d6) δ (ppm) 8.78 (d, J=2.3 Hz, 1H), 8.71 (s, 1H), 8.47 (d, J=8.0 Hz, 1H), 8.26 (m, 2H), 8.22 (m, 1H), 7.92 (d, J=8.2 Hz, 2H), 7.88 (m, 1H), 7.81 (d, J=8.5 Hz, 2H), 7.66 (s, 1H), 7.59 (dd, J=7.9, 1.7 Hz, 1H), 5.80 (s, 2H), 2.54 (s, 3H).
Sources & evidence
- ORD record
- ord-f9fa8b2af4de4d21b5db3aa666e288b5
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08455638B2
Reaction notes
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