HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromotrichloromethane → 5-Bromo-2-[bromo(difluoro)methyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromotrichloromethane | HCID 6383 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5-Bromo-2-(difluoromethyl)benzonitrile | HCID 67159007 | — |
| Product | 5-Bromo-2-[bromo(difluoro)methyl]benzonitrile | HCID 67159102 | — |
Reaction Steps
A mixture of the title compound from Example 302 Step A (2.44 g, 10.5 mmol), CCl3Br (8 mL) and Na2CO3 (480 mg, 4.5 mmol) in a sealed vessel was illuminated by a sunlamp for 30 h. Purification by silica gel flash chromatography using 8:1 to 6:1 to 4:1 hexanes:DCM as mobile phase yielded the title compound: 1H NMR (500 MHz, CD2Cl2) δ 8.03 (s, 1H), 7.92 (d, J=8.5 Hz, 1H), 7.65 (d, J=8.5 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455638B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-78cc48c27a9340cfbd0a72da2252fa6b |
| Source note | uspto-grants-2013_06 |