HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (3-(4-(tert-Butyldimethylsilyloxy)but-1-ynyl)phenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (But-3-yn-1-yloxy)(tert-butyl)dimethylsilane | HCID 4304567 | — |
| Reactant | 3-(3-(Hydroxymethyl)phenyl)propan-1-ol | HCID 55267680 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | (3-(4-(tert-Butyldimethylsilyloxy)but-1-ynyl)phenyl)methanol | HCID 58168614 | — |
Reaction Steps
Prepared by the method of Aromatic Intermediate 18, step a using tert-butyldimethyl(but-3-ynyloxy)silane (0.92 g) in place of tert-butyldimethyl(prop-2-ynyloxy)silane. The preparative HPLC conditions were changed to XBridge™, Gradient: 75-99% methanol in 0.2% aqueous ammonia to avoid cleavage of the silyl protecting group. Yield 0.79 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455483B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-9d5dc419da804c37b93b1265af03f15b |
| Source note | uspto-grants-2013_06 |