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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1255266Generated: November 1, 2026

3-(3-(Hydroxymethyl)phenyl)propan-1-ol → (3-(4-(tert-Butyldimethylsilyloxy)butyl)phenyl)methanol

https://huagongshe.com/reaction/1255266

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3-(Hydroxymethyl)phenyl)propan-1-olHCID 55267680—
Reactant3-(3-(Hydroxymethyl)phenyl)prop-2-yn-1-olHCID 58168552—
Reactant(3-(4-(tert-Butyldimethylsilyloxy)but-1-ynyl)phenyl)methanolHCID 58168614—
Product(3-(4-(tert-Butyldimethylsilyloxy)butyl)phenyl)methanolHCID 58168515—

Reaction Steps

Prepared by the method of Aromatic Intermediate 18, step b using (3-(4-(tert-butyldimethylsilyloxy)but-1-ynyl)phenyl)methanol [Aromatic Intermediate 19, step a] (0.79 g) in place of 3-(3-(hydroxymethyl)phenyl)prop-2-yn-1-ol. Yield 0.72 g.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08455483B2
Source datasetuspto-grants-2013_06
ORD IDord-dbfe4b0bb52643dd86b2a9c3f5c80923
Source noteuspto-grants-2013_06