Butylamine → HCID 58168553, compound

HRID 1255296Notes

Reaction equation

HRID 1255296 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].Br[CH2:7][CH2:8][CH2:9][O:10][Si:11]([C:14]([CH3:17])([CH3:16])[CH3:15])([CH3:13])[CH3:12]>>[Si:11]([O:10][CH2:9][CH2:8][CH2:7][NH:5][CH2:1][CH2:2][CH2:3][CH3:4])([C:14]([CH3:15])([CH3:16])[CH3:17])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 607486(3-Bromopropoxy)(tert-butyl)dimethylsilane

Product 1

HCID 58168553HCID 58168553, compound

Procedure

Butan-1-amine (8 mL) was added to (3-bromopropoxy)(tert-butyl)dimethylsilane (0.8 g) and the resulting mixture stirred overnight at RT. The volatiles were removed by concentration under reduced pressure and the residue was partitioned between saturated sodium bicarbonate solution (20 mL) and ethyl acetate (25 mL). The phases were separated and the aqueous phase was extracted with more ethyl acetate (2×25 mL). The combined organic phases were washed with brine (25 mL), dried over sodium sulphate, filtered and evaporated to give the titled compound as a clear oil. Yield 0.75 g.

Workup

  1. customThe volatiles were removed by concentration under reduced pressure
  2. customthe residue was partitioned between saturated sodium bicarbonate solution (20 mL) and ethyl acetate (25 mL)
  3. customThe phases were separated
  4. extractionthe aqueous phase was extracted with more ethyl acetate (2×25 mL)
  5. washThe combined organic phases were washed with brine (25 mL)
  6. dry with materialdried over sodium sulphate
  7. filtrationfiltered
  8. customevaporated

Sources & evidence

ORD record
ord-d98099120e9d4f5a8ce7576c0004ea3c
Source dataset
uspto-grants-2013_06
Patent number
US08455483B2

Reaction notes

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