HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2,2-dimethoxyethyl)cyclohexanamine → 3-(2-Chloro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclohexyl-N-(2,2-dimethoxyethyl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2,2-dimethoxyethyl)cyclohexanamine | HCID 3024915 | — |
| Reactant | 3-(2-Chloro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid | HCID 58168459 | — |
| Product | 3-(2-Chloro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)-N-cyclohexyl-N-(2,2-dimethoxyethyl)propanamide | HCID 58168528 | — |
Reaction Steps
Prepared by the method of Example 7, step e using 3-(2-chloro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid [Example 27, step d] (0.28 g) in place of 3-(2-fluoro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid, and N-(2,2-dimethoxyethyl)cyclohexanamine [WO 2008075025] (0.10 g) in place of N-(2,2-dimethoxyethyl)cycloheptanamine. Yield 0.11 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455483B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-783d440685ea4545bd2e6c698e19fb7a |
| Source note | uspto-grants-2013_06 |