Trifluoroacetate → HCID 58168510, compound

HRID 1255349Notes

Reaction equation

HRID 1255349 reaction equation
[CH:1]([C:4]1[S:5][CH:6]=[C:7]([C:9]([N:11]2[CH2:16][C:15]3([CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[O:14][CH2:13][CH2:12]2)=[O:10])[N:8]=1)([CH3:3])[CH3:2].FC(F)(F)C([O-])=O.[C:29]([O:32][CH2:33][CH2:34][C:35]1[S:36][CH:37]=[C:38]([CH2:40][CH2:41]OS(C)(=O)=O)[CH:39]=1)(=[O:31])[CH3:30]>>[C:29]([O:32][CH2:33][CH2:34][C:35]1[S:36][CH:37]=[C:38]([CH2:40][CH2:41][N:19]2[CH2:18][CH2:17][C:15]3([O:14][CH2:13][CH2:12][N:11]([C:9]([C:7]4[N:8]=[C:4]([CH:1]([CH3:3])[CH3:2])[S:5][CH:6]=4)=[O:10])[CH2:16]3)[CH2:21][CH2:20]2)[CH:39]=1)(=[O:31])[CH3:30]

Participants

4

Reactant 3

HCID 84468TrifluoroacetateHCID 57989152(2-Isopropylthiazol-4-yl)-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanoneHCID 58168602HCID 58168602, compound2×

Product 1

HCID 58168510HCID 58168510, compound

Procedure

Prepared by the method of Example 1, step c using the hydrochloride salt of (2-isopropylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone [Example 27, step a] (1 g) in place of its trifluoroacetate salt, and 2-(4-(2-(methylsulfonyloxy)ethyl)thiophen-2-yl)ethyl acetate [Aromatic Intermediate 21] (0.8 g) in place of 4-(2-hydroxyethyl)phenethyl methanesulfonate. Yield 1 g.

Workup

  1. customPrepared by the method of Example 1, step c

Sources & evidence

ORD record
ord-728820c37a544aab8d13135aa9894678
Source dataset
uspto-grants-2013_06
Patent number
US08455483B2

Reaction notes

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