Methanol → HCID 86645267, compound

Participants

Reaction Conditions

Reaction Steps

To a flame-dried 50 mL round-bottom flask is weighed 4-chlororesorcinol (1.44 g, 10 mmole) and diethyl-1,3-acetonedicarboxylate (1.82 mL, 10 mmole) and trifluoroacetic acid (10.0 mL) added. This mixture is heated to reflux (98° C.) in an oil-bath for 18 hours, cooled to room-temperature and poured into ice-water (100 mL) with stirring for 1 hour. The resulting off-white precipitate is filtered and washed with ice-cold water, dried in air and in vacuo overnight to give a yellow crystalline powder (1.29 g, 4.56 mmole, 46%) TLC (irrigant=7:3 ethylacetate:methanol, Rf=0.86).

Provenance & Evidence