Hydrochloric Acid → HCID 131730616, compound

Participants

Reaction Conditions

Reaction Steps

To a dry 100 mL round-bottom flask was added absolute ethanol (50 mL) and the solution cooled to 0° C. (ice-bath) under dry N2(g). Acetyl chloride (5.0 mL) was added slowly with stirring and this solution allowed to stir under anhydrous conditions for 2 hours to prepare anhydrous 1.40 M HCl in ethanol. To this solution was added 4-amino-3-hydroxybenzoic acid (2.50 g, 16.32 mmole) and the mixture allowed to stir as above at room temperature overnight. TLC (irrigant=7:1:1:1 ethylacetate:methanol:water:acetic acid, Rf=0.85) indicated complete conversion to the ethyl ester. Yield 3.5 g (99%).

Provenance & Evidence