1,8-Naphthyridine-2-carboxylic acid → HCID 86650155, compound

HRID 1255394Notes

Reaction equation

HRID 1255394 reaction equation
[F:1][C:2]([C:5]1[N:14]=[C:13]2[C:8]([CH:9]=[C:10]([C:19]([O:21]CC)=[O:20])[C:11]([C:15]([F:18])([F:17])[F:16])=[N:12]2)=[CH:7][C:6]=1[F:24])([F:4])[CH3:3].N1C2C(=CC=CN=2)C=CC=1C(O)=O>>[F:4][C:2]([C:5]1[N:14]=[C:13]2[C:8]([CH:9]=[C:10]([C:19]([OH:21])=[O:20])[C:11]([C:15]([F:17])([F:18])[F:16])=[N:12]2)=[CH:7][C:6]=1[F:24])([F:1])[CH3:3]

Participants

3

Reactant 2

HCID 7351561,8-Naphthyridine-2-carboxylic acidHCID 86650156HCID 86650156, compound

Product 1

HCID 86650155HCID 86650155, compound

Procedure

In a similar procedure to Example 1, Stage 2, ethyl 7-(1,1-difluoroethyl)-6-fluoro-2-trifluoromethyl-[1,8]-naphthyridine-3-carboxylate was hydrolysed to the required naphthyridine carboxylic acid as a colourless solid. 1H NMR (CDCl3) δ: 9.15 (1H, s), 8.80 (1H, d), 2.20 (3H, t). Molecular ion: (MH)+325.)

Sources & evidence

ORD record
ord-408d13a258c94c44b9820be965529354
Source dataset
uspto-grants-2013_06
Patent number
US08461083B2

Reaction notes

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