HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-methylpyridine → N-(5-Fluoro-6-methylpyridin-2-yl)pivalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-methylpyridine | HCID 15765 | — |
| Reactant | N-(6-Methylpyridin-2-yl)pivalamide | HCID 3251458 | — |
| Reactant | 5-Fluoro-6-methylpyridin-2-amine | HCID 13789841 | — |
| Product | N-(5-Fluoro-6-methylpyridin-2-yl)pivalamide | HCID 66602030 | — |
Reaction Steps
In a similar procedure, N-(6-methylpyridin-2-yl)-2,2-dimethylpropionamide was prepared from 2-amino-6-methylpyridine. 1H NMR (CDCl3) δ: 8.02-8.04 (1H, d), 7.95 (1H, broad s), 7.54-7.60 (1H, t), 6.86-6.88 (1H, d), 2.44 (3H, s), 1.31 (9H, s). Similarly, N-(5-fluoro-6-methylpyridin-2-yl)-2,2-dimethylpropionamide was prepared from 2-amino-5-fluoro-6-methylpyridine. 1H NMR (CDCl3) δ: 8.02 (1H, dd), 7.95 (1H, broad s), 7.35 (1H, t), 2.44 (3H, d), 1.32 (9H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461083B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-f22e9cd1d1ad49b1b13ecc6f4a851295 |
| Source note | uspto-grants-2013_06 |