HCID 45120113, compound → HCID 66602031, compound

Participants

Reaction Steps

To a stirred suspension of 3-chloro-8-oxa-bicyclo[3.2.1]oct-6-ene-2,4-dione (6.44 g) in aqueous hydrochloric acid (35 ml, 2M) was added zinc powder (4.88 g) in portions maintaining the reaction temperature below 25° C. by cooling with an icebath. After 45 minutes, the mixture was filtered through a bed of celite then extracted with ethyl acetate. the extract was dried over magnesium sulfate, filtered and evaporated under reduced pressure to afford the required product. 1H NMR (d6-DMSO) δ: 6.50 (2H, s), 5.18 (2H, s), 4.15 (1H, d), 3.34 (1H, d).

Provenance & Evidence