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HRID1255419

反应详情

EQUATION

反应方程式

HRID 1255419 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N1CCC(Oc2cc3ccnc(OCc4ccccc4)c3cc2Cl)CC1
HCID57652511

未命名化合物

PRODUCTS

生成物

1
结构：Cl.O=c1[nH]ccc2cc(OC3CCNCC3)c(Cl)cc12
HCID67458042

7-Chloro-6-[(piperidin-4-yl)oxy]isoquinolin-1(2H)-one--hydrogen chloride (1/1)

C14H16Cl2N2O2

收率 69.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

254 mg (0.52 mmol) of 4-(1-Benzyloxy-7-chloro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl-ester (6) were stirred in methanol/2 N HCl (1:1) at room temperature overnight. The solvent was removed i. vac. and the residue was purified by preparative HPLC. The product fractions were evaporated and dissolved in 2 N HCl. Lyophilization results in 57 mg of the desired compound. Rt=0.95 min (Method B). Detected mass: 279.1 (M+H+).

WORKUP

后处理

  1. customThe solvent was removed i
  2. customand the residue was purified by preparative HPLC
  3. customThe product fractions were evaporated
  4. dissolutiondissolved in 2 N HCl