HCID 58484971, compound → HCID 86658721, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R)-methyl 1-(((2-chloro-5-nitropyrimidin-4-yl)(3,3-difluorocyclopentyl)amino)methyl)cyclopropane-carboxylate (3.90 g, 9.98 mmol) and iron powder (1.143 g, 20.46 mmol) in glacial acetic acid (50 mL) was heated to 70° C. for 2 hours. The reaction mixture was filtered hot and the cake was further washed with acetic acid. The mother liquors were concentrated in vacuo. The residue was taken up in a 15% solution of methanol in dichloromethane and filtered through a path of silica gel rinsing with more methanol-dichloromethane solution. The mother liquors were concentrated in vacuo. The residue was triturated with methanol and the solid was filtered to afford the desired compound as a light pink solid (1.953 g, 60% yield).

Provenance & Evidence