Hydrochloric Acid → HCID 67444615, compound

Participants

Reaction Conditions

Reaction Steps

(R)-tert-butyl 2-((R)-3,3-difluorocyclopentyl amino)butanoate (1.0 g, 3.798 mmol) was dissolved in methanol (70 mL) and cooled down to 0° C. The resultant mixture was saturated with HCl gas, then stirred at room temperature for 3 hours. The reaction mixture was warmed to 40° C. for 90 minutes then concentrated under reduced pressure. The residue was partitioned between DCM and an aqueous solution of NaHCO3. The aqueous phase was extracted with DCM three times, dried over magnesium sulfate and concentrated under reduced pressure to afford the desired product as colourless oil (645 mg, 78% yield).

Provenance & Evidence