Methyl iodide → HCID 58484974, compound

Participants

Reaction Steps

60% sodium hydride in mineral oil (22.41 mg, 0.56 mmol) was added to a mixture of (R)-2-chloro-8-((R)-3,3-difluorocyclopentyl)-7-ethyl-7,8-dihydropteridin-6(5H)-one (169 mg, 0.53 mmol) and methyl iodide (36.54 μL, 0.59 mmol) in dimethylacetamide (1.7 mL). The reaction mixture was stirred at room temperature for 1 hour. Ice was added to the reaction mixture. A solid crashed out and was filtered off, rinsing with water. The solid was dried in a pistol under vacuo at 70° C. The compound was obtained as a white solid (165 mg, 94% yield).

Provenance & Evidence