HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N'-Dimethylethylenediamine → 1-[5-Phenyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| Reactant | Triethylaluminum | HCID 16682930 | — |
| Reactant | Ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate | HCID 68407826 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-[5-Phenyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one | HCID 25033168 | — |
Reaction Steps
Following General Procedure O, 5-phenyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid ethyl ester (Compound 29, 292 mg, 0.71 mmol) in toluene (5 ml), N,N′-dimethylethylenediamine (DMEDA, 76 mg, 0.86 mmol) and triethylaluminum (2.4 ml, 0.35 mmol, 1 M in hexane) were reacted to produce the title compound as a oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728014B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-fec3f79e1b134d3c9cf24eaca51232e1 |
| Source note | uspto-grants-2010_06 |