HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(methylcarbamothioyl)carbamate → [(S)-1,4-dimethyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(methylcarbamothioyl)carbamate | HCID 57496573 | — |
| Reactant | (S)-3-amino-3-(3-nitro-phenyl)-butyric acid methyl ester | HCID 57505082 | — |
| Product | [(S)-1,4-dimethyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester | HCID 57496576 | — |
Reaction Steps
Starting from (S)-3-amino-3-(3-nitro-phenyl)-butyric acid methyl ester (21 mmole) and tert-butyl [(methylamino)carbonothioyl]carbamate, the product [(S)-1,4-dimethyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (7.22 g) was obtained as white solid. MS (ESI): m/z=361.4 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08461160B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-b0c856081cc5475990c89296ddc32f9e |
| Source note | uspto-grants-2013_06 |