Nicotinic Acid → HCID 49820222, compound

HRID 1255789Notes

Reaction equation

C(OC(=O)[NH:7][C:8]1[N:9]([CH3:23])[C:10](=[O:22])[CH2:11][C@:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH2:21])[CH:16]=2)([CH3:14])[N:13]=1)(C)(C)C.[C:25](O)(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[N:28][CH:27]=1>>[NH2:7][C:8]1[N:9]([CH3:23])[C:10](=[O:22])[CH2:11][C@:12]([C:15]2[CH:16]=[C:17]([NH:21][C:25](=[O:32])[C:26]3[CH:31]=[CH:30][CH:29]=[N:28][CH:27]=3)[CH:18]=[CH:19][CH:20]=2)([CH3:14])[N:13]=1

Participants

Reactant 2

HCID 938Nicotinic Acid

HCID 57496586HCID 57496586, compound

Product 1

HCID 49820222HCID 49820222, compound

Procedure

The coupling of [(S)-4-(3-amino-phenyl)-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester from experiment F1 and nicotinic acid followed by deprotection of the intermediate yielded the title compound as a colourless solid. MS (ESI): m/z=338.4 [ M+H]+.

Sources & evidence

ORD record: ord-0845fafeed47459098ce69d3dd8abc89
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08461160B2

Reaction notes

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