Lithium Hydroxide → 5-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid

Participants

Reaction Steps

A solution of 5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid methyl ester (216 mg) in MeOH (1 ml) was treated with a solution of LiOH (78 mg) in water (0.1 ml) and stirring was continued at 22° C. for 2 h. The solution was evaporated and the residue triturated with 1N aqueous HCl. The suspension was filtered, the residue washed with water and dried to give 5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (125 mg) as a white solid. MS (ESI): m/z=220.1 [M−H]−.

Provenance & Evidence