5-Bromo-2-chloropyrimidine → Pyrimidine, 5-bromo-2-methoxy-

HRID 1255813Notes

Reaction equation

HRID 1255813 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH3:9][O-:10].[Na+]>CO>[Br:1][C:2]1[CH:3]=[N:4][C:5]([O:10][CH3:9])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 10942334Sodium Methoxide

Product 1

HCID 139657Pyrimidine, 5-bromo-2-methoxy-

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-Bromo-2-chloropyrimidine (10 g, 52 mmol) and sodium methoxide (8.42 g, 156 mmol) were taken in methanol (50 mL) and stirred at room temperature overnight. Reaction mixture was concentrated followed by the addition of water. The resulting mixture was extracted with ethyl acetate and dried over MgSO4. The titled compound was obtained after concentration (8.07 g, 82.5%).

Workup

  1. customReaction mixture
  2. concentrationwas concentrated
  3. additionfollowed by the addition of water
  4. extractionThe resulting mixture was extracted with ethyl acetate
  5. dry with materialdried over MgSO4

Sources & evidence

ORD record
ord-fe9b90ccf29d4753a2e48c6d7085ad10
Source dataset
uspto-grants-2013_06
Patent number
US08461157B2

Reaction notes

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