6-Methyl-2-pyridinecarboxaldehyde → (NE)-2-methyl-N-[(6-methyl-2-pyridinyl)methylidene]propane-2-sulfinamide

Participants

Reaction Steps

To a solution of 2-methylpropane-2-sulfinamide (0.18 g, 1.49 mmol) in methylene chloride (3 mL) was added copper sulfate (0.24 g, 1.49 mmol) followed by 6-methylpyridine-2-carbaldehyde (0.2 g, 1.63 mmol). The reaction was stirred at ambient temperature for 16 hours, then filtered through a pad of celite (washing with methylene chloride) and evaporated in vacuo to give crude 2-methyl-N-[(1E)-(6-methylpyridin-2-yl)methylene]propane-2-sulfinamide. LC-MS EIMS: m/z 225.1 [M+H]+.

Provenance & Evidence