反应详情

3-Aminopyrazole (0.75 g, 9.04 mmol) was mixed with (2Z)-2-bromo-3-(dimethylamino)acrylaldehyde obtained at the previous step (1.85 g, 10.4 mmol). Absolute ethanol (20 mL) and glacial acetic acid (2 mL) were added. The reaction mixture was stirred under reflux for 16 h and evaporated to dryness. The residue was washed on a filter with cold ethanol/hexane mixture (3:1) and dried in a vacuum oven at 30° C. to give 6-bromopyrazolo[1,5-a]pyrimidine.

1. customobtained at the previous step (1.85 g, 10.4 mmol)
2. temperatureunder reflux for 16 h
3. customevaporated to dryness
4. washThe residue was washed on
5. filtrationa filter with cold ethanol/hexane mixture (3:1)
6. customdried in a vacuum oven at 30° C.